Sterol biosynthesis and sterol uptake in the fungal pathogen Pneumocystis carinii
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چکیده
منابع مشابه
Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii.
Pneumocystis carinii synthesizes sterols with a double bond at C-7 of the sterol nucleus and an alkyl group with one or two carbons at C-24 of the side chain. Also, some human-derived Pneumocystis carinii f. sp. hominis strains contain lanosterol derivatives with an alkyl group at C-24. These unique sterols have not been found in other pathogens of mammalian lungs. Thus, P. carinii may have imp...
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Laboratorio de Quı́mica Biológica, Centro de Biofı́sica y Bioquı́mica, Instituto Venezolano de Investigaciones Cientı́ficas, Caracas 1020A, Venezuela; Department of Pathology and Laboratory Medicine, Indiana University Medical Center, Indianapolis, Indiana 46202-5120; and Laboratory of Molecular Parasitology, Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 6...
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Sterols are a major component of eukaryotic cell membranes. For human fungal infections caused by the filamentous fungus Aspergillus fumigatus, antifungal drugs that target sterol biosynthesis and/or function remain the standard of care. Yet, an understanding of A. fumigatus sterol biosynthesis regulatory mechanisms remains an under developed therapeutic target. The critical role of sterol bios...
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Trans-(l-aH2]3-methylpent-2-enyl pyrophosphate and [l14C]isopentenyl pyrophosphate were incubated with 10,000 X g supematants of rat liver homogenates. Analyses of the unsaponiiiable material extracted from the incubations by gas-liquid radiochromatography and mass spectrometry revealed the synthesis not only of [14C]squalene but also of [SH, 14C]1 -methylsqualene and of [?H, 14C]1, 24-dimethyl...
متن کاملInborn errors of sterol biosynthesis.
The known disorders of cholesterol biosynthesis have expanded rapidly since the discovery that Smith-Lemli-Opitz syndrome is caused by a deficiency of 7-dehydrocholesterol. Each of the six now recognized sterol disorders-mevalonic aciduria, Smith-Lemli-Opitz syndrome, desmosterolosis, Conradi-Hünermann syndrome, CHILD syndrome, and Greenberg dysplasia-has added to our knowledge of the relations...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2010
ISSN: 0378-1097
DOI: 10.1111/j.1574-6968.2010.02007.x